Understanding how ATM affects DNA repair in immune cells
Defining the mechanistic basis of ATM’s impact on VDJ recombination
['FUNDING_R01'] · MICHIGAN STATE UNIVERSITY · NIH-10827366
This study looks at how a protein called ATM helps fix DNA when it gets damaged, especially in immune cells that are still developing, and it aims to find out how problems with this process might relate to immune disorders.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MICHIGAN STATE UNIVERSITY (nih funded) |
| Locations | 1 site (EAST LANSING, UNITED STATES) |
| Trial ID | NIH-10827366 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the ATM kinase in the DNA damage response, particularly during the process of VDJ recombination in developing lymphocytes. By examining how ATM influences the joining of DNA segments, the study aims to clarify its mechanistic role in regulating DNA repair. The researchers utilize cultured cell lines to explore the effects of ATM inhibition on the recombination process, employing a reductionist approach to identify specific interactions within the RAG complex. This could lead to a better understanding of immune disorders related to DNA damage.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic predispositions to immune disorders, particularly those affected by Ataxia Telangiectasia Syndrome.
Not a fit: Patients with unrelated immune disorders or those not affected by DNA damage-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of immune disorders and lead to improved treatments for conditions like Ataxia Telangiectasia Syndrome.
How similar studies have performed: Previous research has shown promising results in understanding DNA repair mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
EAST LANSING, UNITED STATES
- MICHIGAN STATE UNIVERSITY — EAST LANSING, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MEEK, KATHERYN D — MICHIGAN STATE UNIVERSITY
- Study coordinator: MEEK, KATHERYN D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Ataxia Telangiectasia Syndrome, Louis-Bar Syndrome