Understanding how atherosclerosis affects cognitive impairment and dementia
Mechanisms of cognitive impairment caused by atherosclerosis and red blood cell released ATP
This study is looking at how the buildup of plaque in arteries, which can happen with atherosclerosis, might affect memory and thinking skills, especially in people with Alzheimer's, and it’s for anyone interested in understanding how diet and blood health could help prevent or treat dementia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project ID | NIH-10945013 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which atherosclerosis, a condition characterized by the buildup of plaques in arteries, contributes to cognitive impairment and dementia, particularly Alzheimer's disease. The study utilizes both animal models and human samples to explore how red blood cell-released ATP may play a role in this process. By examining the effects of a high-fat diet on genetically modified mice, the researchers aim to uncover the relationship between vascular health and cognitive function, which could lead to new prevention and treatment strategies for dementia.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for or diagnosed with cognitive impairment or dementia, particularly those with a history of vascular disease.
Not a fit: Patients without cognitive impairment or those not affected by vascular diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for cognitive impairment and dementia related to vascular diseases.
How similar studies have performed: Previous research has indicated a link between vascular health and cognitive function, suggesting that this approach may yield valuable insights, although the specific mechanisms being studied are less explored.
Where this research is happening
Hershey, United States
- Pennsylvania State Univ Hershey Med Ctr — Hershey, United States (Active)
Researchers
- Principal investigator: He, Pingnian — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: He, Pingnian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.