Understanding how ASXL1 affects the production of neutrophils in blood disorders.
Role of ASXL1 in normal and abnormal granulopoiesis.
This study is looking at how changes in the ASXL1 protein affect the production of important white blood cells called neutrophils, which help fight infections, especially in people with certain blood disorders, to find new ways to improve treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11059194 on NIH RePORTER |
What this research studies
This research investigates the role of the ASXL1 protein in the development of neutrophils, which are crucial white blood cells involved in the immune response. By examining how mutations in ASXL1 lead to abnormal neutrophil production, particularly in conditions like myelodysplastic syndromes and myeloproliferative neoplasms, the research aims to uncover the underlying molecular mechanisms. Using advanced techniques such as single cell RNA sequencing, the study seeks to identify how ASXL1 regulates neutrophil development and how its mutations contribute to disease. Ultimately, the goal is to develop new therapies that can correct the defects caused by these mutations.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with myelodysplastic syndromes or myeloproliferative neoplasms, particularly those with ASXL1 mutations.
Not a fit: Patients without blood disorders or those whose conditions do not involve neutrophil abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve outcomes for patients with blood disorders characterized by abnormal neutrophil production.
How similar studies have performed: Other research has shown promising results in understanding the role of genetic mutations in blood disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Maxson, Julia E — Oregon Health & Science University
- Study coordinator: Maxson, Julia E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.