Understanding how astroviruses infect birds and animals
Mechanisms of astrovirus infection
['FUNDING_OTHER'] · UNIVERSITY OF ALABAMA AT BIRMINGHAM · NIH-10919784
This study is looking into how human astroviruses make birds and animals sick, especially causing stomach and brain issues, and aims to find out which parts of the virus are involved in the infection so we can eventually create better treatments or ways to prevent these illnesses.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ALABAMA AT BIRMINGHAM (nih funded) |
| Locations | 1 site (BIRMINGHAM, UNITED STATES) |
| Trial ID | NIH-10919784 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which astroviruses, particularly human astrovirus, infect birds and animals, leading to conditions like gastroenteritis and encephalitis. The study aims to identify the specific viral proteins involved in the infection process and how they interact with host cells. By utilizing advanced techniques such as CRISPR-based screens, researchers will explore the host factors that regulate astrovirus infection and the cellular changes that occur during the infection. This foundational knowledge could pave the way for developing targeted treatments or preventive measures against astrovirus-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced gastroenteritis or encephalitis linked to astrovirus infections.
Not a fit: Patients with infections caused by other viruses or unrelated conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for infections caused by astroviruses.
How similar studies have performed: While research on astroviruses is ongoing, this specific investigation into their infection mechanisms is relatively novel and has not been extensively studied.
Where this research is happening
BIRMINGHAM, UNITED STATES
- UNIVERSITY OF ALABAMA AT BIRMINGHAM — BIRMINGHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LENNEMANN, NICHOLAS J — UNIVERSITY OF ALABAMA AT BIRMINGHAM
- Study coordinator: LENNEMANN, NICHOLAS J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.