Understanding how astrocytes interact with the blood-brain barrier in stroke conditions
Deciphering Mechanisms of Astrocyte-BBB Interaction in Normal and Ischemic Stroke
This study is looking at how certain brain cells help keep the blood-brain barrier healthy, especially during and after a stroke, to find new ways to protect the brain and improve recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11057550 on NIH RePORTER |
What this research studies
This research investigates the role of astrocytes, a type of brain cell, in maintaining the blood-brain barrier (BBB), which is crucial for brain health. The study aims to uncover how these cells interact with blood vessels, especially during and after ischemic stroke, a condition where blood flow to the brain is disrupted. By using genetically modified mice, researchers will explore the mechanisms that lead to BBB dysfunction and identify potential targets for treatment. This could help in developing therapies to protect the brain after a stroke.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have experienced an ischemic stroke or are at risk for such events.
Not a fit: Patients with non-ischemic strokes or other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve recovery and outcomes for stroke patients by protecting the blood-brain barrier.
How similar studies have performed: Previous research has shown promising results in understanding astrocyte functions in other neurological conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Lee, Hyun Kyoung — Baylor College of Medicine
- Study coordinator: Lee, Hyun Kyoung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.