Understanding how astrocytes interact with the blood-brain barrier in stroke conditions
Deciphering Mechanisms of Astrocyte-BBB Interaction in Normal and Ischemic Stroke
This study is looking at how certain brain cells help keep the protective barrier around the brain healthy, especially during a stroke, to find new ways to help the brain recover after such an event.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10996144 on NIH RePORTER |
What this research studies
This research investigates the role of astrocytes, a type of brain cell, in maintaining the blood-brain barrier (BBB), which is crucial for brain health. The study focuses on how these cells interact with blood vessel cells, especially during ischemic stroke, a condition where blood flow to the brain is reduced. By using genetically modified mice, researchers aim to uncover the mechanisms that lead to BBB disruption and identify potential targets for treatment. This could help in developing therapies to protect the brain after a stroke.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have experienced an ischemic stroke or are at risk for such events.
Not a fit: Patients with non-ischemic strokes or other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect the brain from damage during and after a stroke.
How similar studies have performed: Previous research has shown promising results in understanding astrocyte functions and their role in brain health, indicating that this approach could yield valuable insights.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Lee, Hyun Kyoung — Baylor College of Medicine
- Study coordinator: Lee, Hyun Kyoung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.