Understanding how astrocytes control brain responses to stress and fear
Control of ETV1 transcriptional networks in amygdalar astrocytes
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10993145
This study is looking at how special brain cells called astrocytes help control fear and stress responses in the amygdala, and it aims to find new ways to help people with anxiety and stress-related issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10993145 on ClinicalTrials.gov |
What this research studies
This research investigates the role of astrocytes, a type of glial cell in the brain, in regulating neural activity in the amygdala, which is crucial for processing fear and stress responses. The study employs a novel genetic screening method called SPEAC-seq to explore how astrocytes interact with other brain cells and manage inflammatory signals that can heighten fear responses. By understanding these mechanisms, the research aims to uncover new pathways that could be targeted for therapeutic interventions in anxiety and stress-related disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing anxiety or stress-related disorders.
Not a fit: Patients with non-neurological conditions or those not experiencing anxiety or stress-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for anxiety and stress-related conditions by targeting the interactions between astrocytes and other brain cells.
How similar studies have performed: Previous research has shown promising results in understanding the role of glial cells in brain function, suggesting that this approach could yield significant insights.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WHEELER, MICHAEL ALEX — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: WHEELER, MICHAEL ALEX
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.