Understanding how astrocytes contribute to inflammation in multiple sclerosis
Molecular Control of Astrocytes in CNS Inflammation
This study is looking at how certain brain cells called astrocytes behave during inflammation in multiple sclerosis (MS) to find new ways to improve treatments for people with this condition, especially those in the later stages.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11032049 on NIH RePORTER |
What this research studies
This research investigates the role of astrocytes, a type of brain cell, in the inflammation associated with multiple sclerosis (MS), a debilitating condition affecting many young adults. The study aims to uncover the mechanisms that lead to the activation of these cells during chronic inflammation, which may contribute to the progression of MS. By exploring how environmental factors influence astrocyte behavior, the research seeks to identify new therapeutic targets that could lead to better treatments for MS, especially in its progressive stages. The approach includes using animal models to simulate the disease and test potential interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple sclerosis, particularly those experiencing progressive symptoms.
Not a fit: Patients with other neurological disorders unrelated to inflammation or those who do not have a diagnosis of multiple sclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that more effectively manage or even halt the progression of multiple sclerosis.
How similar studies have performed: Previous research has shown promise in targeting astrocyte activity in other inflammatory conditions, suggesting that this approach may yield beneficial results for MS as well.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Wheeler, Michael Alex — Brigham and Women's Hospital
- Study coordinator: Wheeler, Michael Alex
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.