Understanding how asthma develops in young children at risk
Critical Windows in the Development of Asthma Endotypes and Phenotypes in High-Risk Toddlers
This study is looking at how asthma develops in young children, especially those from low-income urban families, by tracking toddlers who have had wheezing episodes to find out when certain changes in their bodies happen that might lead to asthma, with the goal of helping to prevent it in the future.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11078782 on NIH RePORTER |
What this research studies
This research investigates the development of asthma in high-risk toddlers, particularly those from urban low-income families. It focuses on identifying critical periods in early life when specific biological changes occur that may lead to asthma. By following toddlers aged 1.5 to 3 years who have experienced multiple wheezing episodes, the study aims to map the molecular changes associated with asthma development over four years. This approach could help in creating targeted prevention strategies for asthma in children.
Who could benefit from this research
Good fit: Ideal candidates for participation are toddlers aged 1.5 to 3 years from urban low-income families with a history of frequent wheezing or asthma episodes.
Not a fit: Patients who do not have a history of wheezing or asthma episodes, or those outside the specified age range, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for asthma in young children, potentially reducing the incidence and severity of the condition.
How similar studies have performed: Previous research has shown promise in understanding asthma endotypes, but this specific approach to mapping early-life development is relatively novel.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Liu, Andrew H — University of Colorado Denver
- Study coordinator: Liu, Andrew H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.