Understanding how asthma affects immune responses to COVID-19 in children
Official title: Determinants of Convalescent and Vaccine-induced Mucosal Specific Immunity to SARS-CoV-2 and Variants of Concern in Children with Asthma
Funded at University of Virginia · NIH-11010411 · Data updated 2026-11-12
This study is looking at how kids with asthma react to COVID-19 and its vaccines by checking their immune system's response, so we can better understand how to protect them and improve their treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $678,376 |
| NIH project number | 5R01AI176171-03 |
| Project ID | NIH-11010411 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years with asthma, particularly those who are poorly controlled and may be receiving high-dose corticosteroids.
✕Less likely to help
Patients without asthma or those over the age of 11 may not benefit from this research.
What this research studies
This research investigates how children with asthma respond to COVID-19 infections and vaccinations, focusing on their immune system's ability to fight off the virus and its variants. The study will analyze blood and respiratory samples to measure immune responses, including antibodies and T and B cell activity. By comparing children with asthma to healthy controls, the research aims to identify factors that influence immune responses in these at-risk populations. The findings could help improve vaccination strategies and treatments for children with asthma.
Why it matters
Potential benefit: If successful, this research could lead to better vaccination strategies and treatments for children with asthma, enhancing their protection against COVID-19.
How similar studies have gone: Other research has shown that understanding immune responses in at-risk populations can lead to significant advancements in treatment and prevention strategies.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Teague, William Gerald — University of Virginia
- Study coordinator: Teague, William Gerald
Related research
Other NIH-funded projects on the same topics.
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How SARS-CoV-2 infection affects immune responses in children with and without asthma
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How COVID-19 infection and genes may influence memory and dementia risk
This study looks at how getting COVID-19 and a person’s genes together affect the chance of developing memory problems and Alzheimer’s disease later in life.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.