Understanding how asthma affects immune responses to COVID-19 in children
Determinants of Convalescent and Vaccine-induced Mucosal Specific Immunity to SARS-CoV-2 and Variants of Concern in Children with Asthma
This study is looking at how kids with asthma react to COVID-19 and its vaccines by checking their immune system's response, so we can better understand how to protect them and improve their treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11010411 on NIH RePORTER |
What this research studies
This research investigates how children with asthma respond to COVID-19 infections and vaccinations, focusing on their immune system's ability to fight off the virus and its variants. The study will analyze blood and respiratory samples to measure immune responses, including antibodies and T and B cell activity. By comparing children with asthma to healthy controls, the research aims to identify factors that influence immune responses in these at-risk populations. The findings could help improve vaccination strategies and treatments for children with asthma.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years with asthma, particularly those who are poorly controlled and may be receiving high-dose corticosteroids.
Not a fit: Patients without asthma or those over the age of 11 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better vaccination strategies and treatments for children with asthma, enhancing their protection against COVID-19.
How similar studies have performed: Other research has shown that understanding immune responses in at-risk populations can lead to significant advancements in treatment and prevention strategies.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Teague, William Gerald — University of Virginia
- Study coordinator: Teague, William Gerald
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.