Understanding How Asprosin Affects Appetite in the Brain
The CNS Receptor For Asprosin
['FUNDING_R01'] · CASE WESTERN RESERVE UNIVERSITY · NIH-11168695
This research aims to discover how a hormone called asprosin works in the brain to control appetite, which could help us understand and treat obesity.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11168695 on ClinicalTrials.gov |
What this research studies
Asprosin is a hormone that increases appetite and glucose production, and its levels are often high in people with obesity. This project is looking for the specific part of brain cells, called a receptor, that asprosin connects to. By finding this receptor, we can learn how asprosin signals the brain to feel hungry. This knowledge could lead to new ways to manage appetite and body weight, potentially offering new strategies for obesity treatment.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but future studies based on this work might seek adults with obesity.
Not a fit: Patients not experiencing issues with appetite regulation or obesity would likely not benefit from treatments developed from this specific line of research.
Why it matters
Potential benefit: If successful, this could lead to new medications that block asprosin's effects, helping people with obesity manage their appetite and weight.
How similar studies have performed: While asprosin's role in appetite and glucose has been observed, identifying its specific brain receptor is a novel and crucial step for developing targeted therapies.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHOPRA, ATUL — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: CHOPRA, ATUL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.