Understanding how Aspergillus fumigatus invades the body and affects immune response
Bidirectional paracrine signaling in the establishment of invasive aspergillosis
This study is looking at how a common fungus called Aspergillus fumigatus affects the body and interacts with our immune system, with the goal of finding better ways to treat infections for people who are at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11042273 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the fungus Aspergillus fumigatus invades host tissues and how it interacts with the immune system. It focuses on a unique signaling system involving lipid molecules that facilitate communication between the fungus and the host's immune cells. By identifying specific molecules and their receptors, the research aims to uncover new strategies to enhance antifungal therapies and improve patient outcomes. The approach combines molecular biology techniques with pharmacological studies to manipulate these signaling pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are immunocompromised patients who are at high risk for invasive aspergillosis.
Not a fit: Patients with non-fungal infections or those who are not immunocompromised may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective antifungal treatments for patients suffering from invasive aspergillosis.
How similar studies have performed: Other research has shown promise in targeting similar signaling pathways in fungal infections, indicating potential for success in this approach.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Keller, Nancy P — University of Wisconsin-Madison
- Study coordinator: Keller, Nancy P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.