Understanding how arterial stiffness affects blood vessel cells
Official title: Biomimetic Vascular Matrix for Vascular Smooth Muscle Cell Mechanobiology and Pathology
Funded at State University of New York at Buffalo · NIH-10757729 · Data updated 2026-11-12
This study is looking at how stiff arteries affect certain cells in your blood vessels that can lead to heart problems, and it aims to find new ways to treat these issues by using special lab techniques with both mouse and human cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | September 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $547,055 |
| NIH project number | 5R01HL163168-02 |
| Project ID | NIH-10757729 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for cardiovascular diseases, particularly those with conditions that may lead to arterial stiffness.
✕Less likely to help
Patients with non-cardiovascular conditions or those who do not exhibit arterial stiffness may not benefit from this research.
What this research studies
This research investigates the relationship between arterial stiffness and the behavior of vascular smooth muscle cells (VSMCs), which play a crucial role in cardiovascular diseases. By using advanced 3D cell culture techniques, the study will explore how changes in the extracellular matrix (ECM) influence VSMC migration and proliferation, contributing to conditions like atherosclerosis. The research will involve both mouse and human cells to assess these processes at a single-cell level and in more complex models. Ultimately, the goal is to identify key mechanisms that could lead to new therapeutic strategies for cardiovascular diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or mitigate cardiovascular diseases by targeting the mechanisms of arterial stiffness.
How similar studies have gone: Previous research has shown promising results in understanding the role of the extracellular matrix in vascular biology, suggesting that this approach could yield valuable insights.
Where this research is happening
-
State University of New York at Buffalo
Amherst, United States Active
Researchers
- Principal investigator: Bae, Yongho — State University of New York at Buffalo
- Study coordinator: Bae, Yongho
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.