Understanding how arsenic exposure leads to cancer stem-like cells
Dissecting Nrf2-dependent HIF1a activation mechanism in arsenic-induced cancer stem-like cells
['FUNDING_R01'] · STATE UNIVERSITY NEW YORK STONY BROOK · NIH-10973189
This study is looking at how long-term exposure to arsenic can change normal cells into cancer-like cells, focusing on certain pathways in the body, and it aims to find ways to create better treatments for cancers caused by arsenic.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STATE UNIVERSITY NEW YORK STONY BROOK (nih funded) |
| Locations | 1 site (STONY BROOK, UNITED STATES) |
| Trial ID | NIH-10973189 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which long-term exposure to inorganic arsenic can transform normal cells into cancer stem-like cells (CSCs). It focuses on the activation of specific signaling pathways, particularly Nrf2 and HIF1α, which are believed to play a crucial role in this transformation. By using advanced techniques like ChIP-seq and biochemical assays, the study aims to uncover the metabolic and epigenetic changes that occur in cells exposed to arsenic. This knowledge could help in developing targeted therapies for arsenic-induced cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of arsenic exposure, particularly those at risk for lung cancer.
Not a fit: Patients who have not been exposed to arsenic or do not have a related cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers associated with arsenic exposure.
How similar studies have performed: While the specific mechanisms of arsenic-induced CSCs are not extensively studied, similar research has shown promising results in understanding cancer stem cell biology.
Where this research is happening
STONY BROOK, UNITED STATES
- STATE UNIVERSITY NEW YORK STONY BROOK — STONY BROOK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, FEI — STATE UNIVERSITY NEW YORK STONY BROOK
- Study coordinator: CHEN, FEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: arsenic induced cancer