Understanding how arsenic affects specific genes in the body
Official title: Role of epigenetic crosstalks in directing locus sensitivity to arsenic
Funded at University of California Los Angeles · NIH-10973598 · Data updated 2026-11-12
This study is looking at how some people's genes react differently to arsenic, a common toxin, and aims to find out why some individuals are more impacted than others, which could help improve health for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | January 25, 2023 |
| Project end | October 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $497,452 |
| NIH project number | 5R01ES034251-03 |
| Project ID | NIH-10973598 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been exposed to arsenic or are at risk due to environmental factors.
✕Less likely to help
Patients who have no history of arsenic exposure or related health issues may not benefit from this research.
What this research studies
This research investigates how certain genes are more sensitive to arsenic exposure than others, focusing on the role of epigenetic changes. By studying the effects of inorganic arsenic, a common environmental toxin, the researchers aim to uncover the mechanisms that lead to varying responses in gene regulation. The study employs advanced techniques such as bisulfite sequencing and RNA sequencing to analyze DNA and histone modifications in cells. This could help identify why some individuals are more affected by arsenic than others.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of arsenic exposure risks for patients.
How similar studies have gone: Previous research has shown promising results in understanding the effects of environmental toxins on gene regulation, indicating that this approach has potential for success.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Allard, Patrick — University of California Los Angeles
- Study coordinator: Allard, Patrick
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.