Understanding how ARID1 proteins influence the development of cranial neural crest cells
Official title: ARID1 proteins orchestrate cranial neural crest differentiation
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11127195 · Data updated 2026-11-12
This study is looking at how certain proteins called ARID1A and ARID1B help shape the cells that form the face and skull, which could help us understand and improve treatments for conditions like Coffin-Siris Syndrome that affect facial development.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | June 16, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $493,458 |
| NIH project number | 1R01DE033986-01A1 |
| Project ID | NIH-11127195 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with craniofacial anomalies or genetic conditions related to ARID1 mutations.
✕Less likely to help
Patients without craniofacial disorders or those not affected by ARID1-related conditions may not receive any benefit from this research.
What this research studies
This research investigates the role of ARID1 proteins in the differentiation of cranial neural crest cells (CNCCs), which are crucial for craniofacial development. By examining how these proteins regulate cellular processes such as multipotency and migration, the study aims to uncover the molecular mechanisms behind craniofacial anomalies. The approach involves analyzing the expression and function of ARID1A and ARID1B proteins during the development of CNCCs, using advanced cellular models. Patients may benefit from insights gained into genetic disorders like Coffin-Siris Syndrome, which is linked to mutations in these proteins.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for craniofacial disorders.
How similar studies have gone: Other research has shown success in understanding the roles of transcription factors in cellular differentiation, suggesting that this approach may yield valuable insights.
Where this research is happening
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Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Brugmann, Samantha a — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Brugmann, Samantha a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.