Understanding how arginase-1 helps the brain recover after a stroke in newborns
Official title: Arginase-1 signaling after neonatal stroke
Funded at University of California, San Francisco · NIH-11042748 · Data updated 2026-11-12
This study is looking at how a protein called arginase-1 helps newborns' brains heal after a stroke caused by a lack of oxygen, with the hope of finding new ways to support their recovery.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | April 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $196,169 |
| NIH project number | 5K08NS125042-03 |
| Project ID | NIH-11042748 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are infants aged 0-11 years who have suffered a hypoxic-ischemic stroke.
✕Less likely to help
Patients who have not experienced a stroke or are older than 11 years may not benefit from this research.
What this research studies
This research investigates the role of arginase-1 (ARG-1) in the brain's recovery process following a hypoxic-ischemic stroke in newborns. The study focuses on how ARG-1 contributes to neuroprotection and tissue regeneration by facilitating the removal of dead cells and supporting the formation of scar tissue. Researchers will use a specific animal model to observe changes in ARG-1 activity and its effects on brain recovery over time. By understanding these mechanisms, the research aims to identify potential therapeutic targets for improving outcomes in affected infants.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance brain recovery in infants who have experienced a stroke.
How similar studies have gone: Previous research has shown promising results in understanding the role of arginase-1 in other organs, but its specific effects in the neonatal brain after stroke are still being explored.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Mike, Jana Krystofova — University of California, San Francisco
- Study coordinator: Mike, Jana Krystofova
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.