Understanding how ARF6 affects cancers caused by RAS mutations
ARF6 function in cancers driven by RAS hyperactivation
This study is looking at how a protein called ARF6 affects cancer growth in people with Neurofibromatosis type 1, especially those with a type of cancer linked to a hyperactive RAS gene, to help find better treatment options.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-10675597 on NIH RePORTER |
What this research studies
This research investigates the role of the small GTPase protein ARF6 in cancers driven by hyperactivated RAS, particularly in patients with Neurofibromatosis type 1 (NF1). The study aims to uncover how ARF6 influences RAS signaling and tumor cell proliferation, which could lead to new therapeutic strategies. By examining the mechanisms of ARF6 in regulating RAS trafficking and its effects on cancer growth, the research seeks to provide insights that could improve treatment options for patients with RAS-driven malignancies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Neurofibromatosis type 1 or those with RAS-driven cancers such as malignant peripheral nerve sheath tumors.
Not a fit: Patients without RAS mutations or those not diagnosed with related cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for patients with cancers associated with RAS hyperactivation.
How similar studies have performed: While targeting RAS has been challenging, the investigation of ARF6 in this context is a novel approach that has not been extensively tested in clinical settings.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Yoo, Jae Hyuk — University of Nebraska Medical Center
- Study coordinator: Yoo, Jae Hyuk
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.