Understanding how archaeal microorganisms manage their DNA and gene expression.
Official title: Archaeal Chromosome Dynamics
Funded at Ohio State University · NIH-11206377 · Data updated 2026-11-12
This study is exploring how tiny microorganisms called archaea copy their DNA and use their genes, which could help us understand important biological processes that are similar in many living things.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $507,935 |
| NIH project number | 7R35GM152171-02 |
| Project ID | NIH-11206377 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in the fundamental biological processes of DNA and gene regulation, particularly those with a background in microbiology or genetics.
✕Less likely to help
Patients with no interest or background in molecular biology or those not engaged in scientific research may not find direct benefits from this research.
What this research studies
This research focuses on the molecular biology of archaea, a group of microorganisms that share evolutionary ties with eukaryotes. The project investigates how these organisms replicate their DNA and express their genes, using both laboratory techniques and live cell observations. By studying the unique structural organization of archaeal genomes, particularly in the Sulfolobales order, researchers aim to uncover the mechanisms that govern DNA replication and gene regulation. This work could provide insights into fundamental biological processes that are conserved across different life forms.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of DNA replication and gene expression, potentially leading to advancements in genetic engineering and biotechnology.
How similar studies have gone: Previous research has shown success in understanding DNA replication and gene expression in other organisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Bell, Stephen David — Ohio State University
- Study coordinator: Bell, Stephen David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.