Understanding how apolipoprotein A-II affects cholesterol and triglyceride levels
The molecular basis for the role of apolipoprotein A-II in cholesterol and triglyceride metabolism
This study is looking at a protein called apolipoprotein A-II to see how it affects cholesterol and fat levels in the body, which could help us understand heart health better and find ways to prevent heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10739814 on NIH RePORTER |
What this research studies
This research investigates the role of apolipoprotein A-II, a protein found in high-density lipoproteins, in cholesterol and triglyceride metabolism. The study aims to clarify how this protein influences cardiovascular disease by examining its effects on lipoprotein metabolism and the proteins associated with it. Researchers will utilize advanced techniques like cryo-electron microscopy to explore the structural changes in apolipoprotein A-I when interacting with apolipoprotein A-II. By understanding these mechanisms, the research hopes to provide insights into cardiovascular health and disease prevention.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with elevated cholesterol or triglyceride levels, particularly those at risk for cardiovascular diseases.
Not a fit: Patients with normal cholesterol and triglyceride levels or those not at risk for cardiovascular diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing cholesterol levels and reducing cardiovascular disease risk.
How similar studies have performed: Previous research has shown promising results in understanding the roles of various apolipoproteins in lipid metabolism, suggesting that this approach could yield valuable insights.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Davidson, W Sean — University of Cincinnati
- Study coordinator: Davidson, W Sean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.