Understanding how ApoE4 contributes to Alzheimer's disease
Structural basis for ApoE4-induced Alzheimer's disease
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-11019896
This study is looking at how a specific protein called ApoE4 affects Alzheimer's disease, with the hope of finding new ways to help people understand and manage their risk for this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11019896 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the ApoE4 protein in Alzheimer's disease, which is a leading cause of death in the U.S. The study aims to uncover the structural differences between ApoE4 and other variants, such as ApoE3 and ApoE2, to understand how these differences contribute to neurotoxicity and the development of Alzheimer's. By utilizing advanced modeling techniques, the research seeks to clarify the mechanisms by which ApoE4 increases the risk of Alzheimer's, potentially leading to new therapeutic strategies. Patients may benefit from insights gained into how genetic factors influence Alzheimer's progression.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those who are ApoE4 carriers.
Not a fit: Patients who do not have a genetic predisposition to Alzheimer's disease or those with other forms of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target the mechanisms of Alzheimer's disease, particularly for those at higher genetic risk.
How similar studies have performed: Previous research has shown promising results in understanding the genetic factors of Alzheimer's, making this approach a continuation of established scientific inquiry.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOWMAN, GREGORY — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: BOWMAN, GREGORY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age associated neurodegenerative disease, age associated neurodegenerative disorder, age dependent neurodegenerative disease, age dependent neurodegenerative disorder, age-driven neurodegenerative disorders