Understanding how APOE4 affects Lewy body dementia
Elucidating the Pathomechanisms of APOE4 in Lewy Body Dementia
['FUNDING_R01'] · MAYO CLINIC JACKSONVILLE · NIH-11124664
This study is looking at how a specific gene called APOE4 might affect Lewy body dementia by examining brain samples and models, with the goal of finding new ways to understand and treat this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC JACKSONVILLE (nih funded) |
| Locations | 1 site (JACKSONVILLE, UNITED STATES) |
| Trial ID | NIH-11124664 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which the APOE4 gene variant influences Lewy body dementia (LBD). It focuses on how APOE4 affects the pathology of alpha-synuclein, a protein linked to LBD, using human brain samples, mouse models, and stem cell-derived organoids. By exploring the relationship between APOE4 and LBD, the study aims to identify key molecular pathways and brain regions that are vulnerable to this genetic risk factor. This could lead to a better understanding of LBD and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a genetic predisposition to Lewy body dementia, particularly those carrying the APOE4 allele.
Not a fit: Patients without the APOE4 allele or those with other forms of dementia unrelated to Lewy body pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with Lewy body dementia.
How similar studies have performed: Previous research has shown promising results in understanding the role of APOE4 in other neurodegenerative diseases, suggesting that this approach may yield valuable insights for Lewy body dementia as well.
Where this research is happening
JACKSONVILLE, UNITED STATES
- MAYO CLINIC JACKSONVILLE — JACKSONVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHAO, NA — MAYO CLINIC JACKSONVILLE
- Study coordinator: ZHAO, NA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.