Understanding how ApoE interacts with heparan sulfate in Alzheimer's disease
Official title: ApoE and Heparan Sulfate Interaction in Alzheimer’s Disease
Funded at Rensselaer Polytechnic Institute · NIH-11083740 · Data updated 2026-11-12
This study is looking at how a protein called ApoE and its interactions with certain sugars in the body might affect the risk of developing Alzheimer's disease, helping us understand more about how these factors work together at a cellular level.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rensselaer Polytechnic Institute NIH-funded |
| Lab location | 1 site (Troy, United States) |
| Project start | May 15, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $732,702 |
| NIH project number | 5R01AG087305-02 |
| Project ID | NIH-11083740 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for Alzheimer's disease, particularly those with the ApoE4 allele.
✕Less likely to help
Patients without any genetic predisposition to Alzheimer's disease or those with other forms of dementia may not benefit from this research.
What this research studies
This research investigates the role of Apolipoprotein E (ApoE) and its interactions with heparan sulfate in the development of Alzheimer's disease. The study aims to uncover the molecular mechanisms by which different forms of ApoE influence the risk of Alzheimer's, particularly focusing on how these interactions vary at the cellular level. Researchers will use advanced techniques to analyze these interactions in both cellular and animal models, providing a comprehensive understanding of how ApoE contributes to Alzheimer's pathology.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that target ApoE interactions to reduce the risk or progression of Alzheimer's disease.
How similar studies have gone: Other research has shown promising results in understanding the role of ApoE in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Rensselaer Polytechnic Institute
Troy, United States Active
Researchers
- Principal investigator: Wang, Chunyu — Rensselaer Polytechnic Institute
- Study coordinator: Wang, Chunyu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.