Understanding how APOBEC3 enzymes cause mutations in cancer
Molecular origins and impact of APOBEC3 mutagenesis in cancer
This study is looking at how certain enzymes called APOBEC3 might cause changes in DNA that can lead to cancers like breast and bladder cancer, and it’s for anyone interested in understanding how these changes happen and how we might prevent or treat these cancers better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10894724 on NIH RePORTER |
What this research studies
This research investigates the role of APOBEC3 enzymes in creating mutations that contribute to various cancers, including breast and bladder cancer. By analyzing cancer cell lines with known APOBEC3 activity, the researchers aim to uncover how these enzymes influence cancer development and progression. The study employs advanced bioinformatics and biological assays to quantify the specific contributions of different APOBEC3 members to mutational patterns in cancer genomes. This understanding could lead to new strategies for cancer prevention and treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with breast, bladder, or lung cancers that may exhibit mutations linked to APOBEC3 activity.
Not a fit: Patients with cancers not associated with APOBEC3 mutagenesis or those without identifiable mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide insights that lead to improved cancer prevention and therapeutic strategies.
How similar studies have performed: Previous research has shown promising results in understanding mutational signatures in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Maciejowski, John — Sloan-Kettering Inst Can Research
- Study coordinator: Maciejowski, John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.