Understanding how apelin affects muscle regeneration as we age
Apelin Signaling in Muscle Regeneration
['FUNDING_OTHER'] · UNIVERSITY OF MAINE ORONO · NIH-11080328
This study is looking at how a substance called apelin helps muscles heal and grow back, especially as we get older and face muscle loss, using zebrafish to learn more about how it works with different cells in the body.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MAINE ORONO (nih funded) |
| Locations | 1 site (ORONO, UNITED STATES) |
| Trial ID | NIH-11080328 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the apelin signaling pathway in muscle regeneration, particularly in the context of aging and age-related muscle loss, known as sarcopenia. By using zebrafish as a model, the study aims to explore how apelin influences communication between muscle stem cells, endothelial cells, and immune cells to enhance muscle recovery. The researchers will employ advanced techniques, including pharmacological interventions and single-cell RNA sequencing, to uncover the mechanisms by which apelin promotes muscle health and combats age-related decline.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those over 80 years of age, who are experiencing muscle loss or related mobility issues.
Not a fit: Patients who are younger and do not have age-related muscle decline or sarcopenia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve muscle regeneration and function in older adults, potentially reducing the risks associated with sarcopenia.
How similar studies have performed: Previous studies have shown promising results with apelin treatments in animal models, indicating potential for success in this area of research.
Where this research is happening
ORONO, UNITED STATES
- UNIVERSITY OF MAINE ORONO — ORONO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MADELAINE, ROMAIN — UNIVERSITY OF MAINE ORONO
- Study coordinator: MADELAINE, ROMAIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.