Understanding how APE2 helps repair DNA damage
Official title: Mechanism of APE2 in genome integrity
Funded at University of North Carolina Charlotte · NIH-10754927 · Data updated 2026-11-12
This study is looking at a protein called APE2 to see how it helps fix small breaks in DNA, which can cause problems like cancer and aging, and it's for anyone interested in understanding how our bodies keep our genetic material healthy.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Carolina Charlotte NIH-funded |
| Lab location | 1 site (Charlotte, United States) |
| Project start | December 15, 2022 |
| Project end | November 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $74,321 |
| NIH project number | 5R03CA270663-02 |
| Project ID | NIH-10754927 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for breast cancer or those experiencing age-related health issues linked to DNA damage.
✕Less likely to help
Patients with conditions unrelated to DNA damage or those not at risk for breast cancer may not benefit from this research.
What this research studies
This research investigates the role of a protein called APE2 in repairing single-strand breaks in DNA, which are common types of damage that can lead to cancer and aging. The study will use advanced laboratory techniques to explore how APE2 interacts with DNA and RNA, and how it helps maintain the stability of our genetic material. By examining these processes in model organisms like yeast and using purified proteins, the researchers aim to uncover the molecular mechanisms behind DNA repair. This understanding could provide insights into how to better address DNA damage in human health.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating conditions related to DNA damage, such as breast cancer and age-related diseases.
How similar studies have gone: Previous research has shown success in understanding DNA repair mechanisms, but the specific role of APE2 in this context is still being explored, making this a novel investigation.
Where this research is happening
-
University of North Carolina Charlotte
Charlotte, United States Active
Researchers
- Principal investigator: Yan, Shan — University of North Carolina Charlotte
- Study coordinator: Yan, Shan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.