Understanding how antigen receptors work in the immune system
Official title: Structural and functional integrity of antigen receptors
Funded at Harvard Medical School · NIH-10995112 · Data updated 2026-11-12
This study looks at how different types of antibodies work in our immune system to fight off germs, focusing on the differences between jawed and jawless animals, and it hopes to find new ways to improve treatments for people with immune-related conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $43,456 |
| NIH project number | 1F31AI186232-01 |
| Project ID | NIH-10995112 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with immune system disorders or those interested in the genetic basis of antibody diversity.
✕Less likely to help
Patients with conditions unrelated to immune system function or antibody production may not receive direct benefits from this research.
What this research studies
This research investigates the structural and functional integrity of antigen receptors, which are crucial for the immune system's ability to recognize and respond to pathogens. It explores two types of antibodies: immunoglobulin-based antibodies found in jawed vertebrates and variable lymphocyte receptor-based antibodies found in jawless vertebrates. The study focuses on how these antibodies diversify through genetic mechanisms, particularly in B cells, and aims to uncover the evolutionary differences in their development and function. Patients may benefit from insights gained about antibody diversity and immune responses, which could inform future therapies.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of immune responses and lead to improved treatments for diseases related to antibody function.
How similar studies have gone: Other research has shown success in understanding antibody diversity and immune responses, making this approach promising and relevant.
Where this research is happening
-
Harvard Medical School
Boston, United States Active
Researchers
- Principal investigator: Chen, Jessica Wt — Harvard Medical School
- Study coordinator: Chen, Jessica Wt
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.