Understanding how antifungal resistance develops in the mouths of people with HIV
Official title: Development of antifungal drug resistance in the oral environment over the course of HIV infection
Funded at Cornell University · NIH-10838165 · Data updated 2026-11-12
This study is looking at how some fungi in the mouth become resistant to antifungal medicines in people living with HIV, especially before they start treatment, so we can find better ways to help manage oral infections like thrush.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $314,000 |
| NIH project number | 1R03DE033304-01A1 |
| Project ID | NIH-10838165 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are HIV-positive individuals who have not yet started antiretroviral therapy.
✕Less likely to help
Patients who are HIV-negative or those who are already receiving treatment for HIV may not benefit from this research.
What this research studies
This research investigates the development of antifungal drug resistance in the oral environment of individuals living with HIV. By examining changes in the oral fungal composition and mutations in resistance genes over time, the study aims to uncover novel mechanisms of antifungal resistance. The research will involve a comparison between HIV-positive individuals who have not yet received treatment and HIV-negative controls, utilizing advanced genomic techniques to gather insights that could improve diagnostics and treatment options. The findings could lead to better management of oral fungal infections, particularly candidiasis, which is common among those with compromised immune systems.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for oral fungal infections in HIV-positive patients, enhancing their quality of life.
How similar studies have gone: Previous research has shown promising results in understanding antifungal resistance mechanisms, but this specific approach is relatively novel.
Where this research is happening
-
Cornell University
Ithaca, United States Active
Researchers
- Principal investigator: Goodman, Laura Brunengraber — Cornell University
- Study coordinator: Goodman, Laura Brunengraber
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.