Understanding how antibodies work against HIV-1
Structure-Function Analytics Core
This study is looking at how antibodies help fight HIV-1 by reducing the virus in the body and preventing infection, and it's for anyone interested in understanding how these immune fighters work in both humans and Rhesus macaques to improve treatments and vaccines for HIV.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10894649 on NIH RePORTER |
What this research studies
This research investigates the various activities of antibodies, particularly their role in reducing viral load and blocking HIV-1 acquisition. It focuses on the mechanisms by which antibodies interact with immune cells and how these interactions differ between humans and animal models, specifically Rhesus macaques. By analyzing the structure and function of antibodies, the research aims to uncover insights that can lead to better treatments and vaccines for HIV-1. The approach involves detailed studies of antibody responses and their effects on the immune system in both human and animal models.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for HIV-1 or those living with HIV-1 who may benefit from enhanced antibody therapies.
Not a fit: Patients who are not at risk for HIV-1 or those who do not have HIV-1 are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating HIV-1 infections.
How similar studies have performed: Previous research has shown promising results in understanding antibody functions in viral infections, suggesting that this approach could yield valuable insights.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Tomaras, Georgia Doris — Duke University
- Study coordinator: Tomaras, Georgia Doris
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.