Understanding how antibodies respond to COVID-19
Official title: COVID-19: Significance of Fc properties and functions in antibody responses against SARS-CoV-2
Funded at James J Peters VA Medical Center · NIH-11098444 · Data updated 2026-11-12
This study is looking at how our bodies fight the COVID-19 virus by checking the antibodies made after vaccination or infection, especially in older veterans, to help improve vaccines and treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | James J Peters VA Medical Center NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | January 1, 2022 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| NIH project number | 5I01BX005794-04 |
| Project ID | NIH-11098444 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults, especially veterans, who have received COVID-19 vaccinations or have been infected with the virus.
✕Less likely to help
Patients who are younger and have not been vaccinated or infected with SARS-CoV-2 may not benefit from this research.
What this research studies
This research investigates the immune response to SARS-CoV-2, focusing on the antibodies produced after vaccination or infection. It aims to understand the properties and functions of these antibodies, particularly how they interact with the virus's spike protein. By analyzing blood and saliva samples from veterans, the study seeks to uncover important differences in antibody responses that could inform better vaccine strategies and treatments. The research is particularly relevant for older adults, who are at higher risk for severe COVID-19.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccine designs and therapeutic strategies for COVID-19, particularly for vulnerable populations.
How similar studies have gone: Previous research has shown promising results in understanding antibody responses to other viral infections, suggesting potential for success in this area as well.
Where this research is happening
-
James J Peters VA Medical Center
Bronx, United States Active
Researchers
- Principal investigator: Hioe, Catarina E — James J Peters VA Medical Center
- Study coordinator: Hioe, Catarina E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.