Understanding how antibodies protect against influenza
Defining the Fc-correlates of protection against influenza
This study is looking at how our immune system fights the flu by examining different types of antibodies in people who have been vaccinated, with the goal of finding better ways to protect everyone from the virus and possibly creating a more effective flu vaccine.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10795839 on NIH RePORTER |
What this research studies
This research investigates the immune response to influenza, focusing on how different types of antibodies can provide protection. It aims to identify specific antibody profiles that correlate with effective immunity, particularly looking beyond traditional measures of protection. By analyzing samples from vaccinated individuals, the study seeks to uncover the roles of various immune functions that may contribute to defense against the virus. This could lead to the development of a more effective universal influenza vaccine.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been vaccinated against influenza and are willing to provide blood samples for analysis.
Not a fit: Patients who have not been vaccinated against influenza or those with severe immune deficiencies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the creation of a universal influenza vaccine that offers broader and more effective protection against various strains of the virus.
How similar studies have performed: Previous research has shown promise in identifying immune correlates of protection in animal models, but this approach is relatively novel in human studies.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Lingwood, Daniel — Massachusetts General Hospital
- Study coordinator: Lingwood, Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.