Understanding how antibodies fight human metapneumovirus
Structural and mechanistic insights into antibody neutralization of human metapneumovirus
['FUNDING_R01'] · FLORIDA STATE UNIVERSITY · NIH-11017984
This study is looking at how certain antibodies in our immune system can fight off the human metapneumovirus, which can cause respiratory infections, especially in kids and people with weakened immune systems, to help find better ways to treat these infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FLORIDA STATE UNIVERSITY (nih funded) |
| Locations | 1 site (TALLAHASSEE, UNITED STATES) |
| Trial ID | NIH-11017984 on ClinicalTrials.gov |
What this research studies
This research investigates how the immune system's antibodies can neutralize human metapneumovirus (hMPV), a virus that causes respiratory infections, particularly in children and immunocompromised individuals. By analyzing blood samples, the study aims to identify specific antibodies that effectively target the virus's fusion protein, which is crucial for the virus's ability to infect cells. The researchers will create hybrid cells to produce these antibodies in the lab, allowing for detailed examination of their effectiveness in neutralizing the virus. This work could lead to better understanding and potential treatments for hMPV infections.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and immunocompromised individuals who are at higher risk for severe hMPV infections.
Not a fit: Patients with mild respiratory infections caused by other viruses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective vaccines or therapies for hMPV, improving outcomes for affected patients.
How similar studies have performed: While research on hMPV is ongoing, this specific approach to understanding antibody neutralization is relatively novel and has not been extensively tested.
Where this research is happening
TALLAHASSEE, UNITED STATES
- FLORIDA STATE UNIVERSITY — TALLAHASSEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MOUSA, JARROD — FLORIDA STATE UNIVERSITY
- Study coordinator: MOUSA, JARROD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.