Understanding how antibodies cause kidney transplant rejection
Chronic Antibody-Mediated Rejection of Kidney Allografts
This study is looking at how certain antibodies can cause problems for kidney transplants, and it's for anyone interested in improving the success of these transplants by understanding how the immune system, especially certain immune cells, can affect the process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11012898 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which antibodies lead to both acute and chronic rejection of kidney transplants. Using a novel animal model, the study examines how donor-specific antibodies (DSA) develop and contribute to kidney allograft injury. The researchers focus on the role of immune cells, particularly NK cells, in mediating these rejection processes and how their activation affects transplant outcomes. By understanding these mechanisms, the research aims to identify potential therapeutic targets to improve kidney transplant success.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have received a kidney transplant and are at risk for antibody-mediated rejection.
Not a fit: Patients who have not undergone kidney transplantation or those with other forms of kidney disease unrelated to transplant rejection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing kidney transplant rejection, enhancing graft survival and patient outcomes.
How similar studies have performed: Other research has shown success in understanding antibody-mediated rejection in kidney transplants, but this specific approach using a novel animal model is relatively new and untested.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Fairchild, Robert L — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Fairchild, Robert L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.