Understanding how antibodies can protect against HIV
Mechanisms of Antibody Fc Mediated Protection
['FUNDING_P01'] · DUKE UNIVERSITY · NIH-10894653
This study is looking at how certain antibodies can help protect against HIV, even if they don't directly fight the virus, by working with immune cells, and it's aimed at finding better ways to create vaccines to keep people safe from HIV.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10894653 on ClinicalTrials.gov |
What this research studies
This research investigates the role of antibodies in providing protection against HIV by focusing on their ability to neutralize the virus and recruit immune cells to fight it. The study aims to explore how certain antibodies, even those that do not neutralize the virus directly, can still contribute to immunity through their interactions with immune cells. By using animal models, the researchers will identify the most effective ways to harness these antibody functions for developing HIV prevention strategies. The ultimate goal is to improve vaccine design and enhance protection against HIV infection.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at high risk of HIV exposure or those interested in HIV prevention strategies.
Not a fit: Patients who are already living with HIV or those who do not have any risk factors for HIV exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective HIV vaccines and prevention methods, potentially reducing the incidence of HIV infections.
How similar studies have performed: Previous research has shown promise in understanding antibody functions in HIV prevention, but this specific approach focusing on Fc-mediated immunity is relatively novel.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TOMARAS, GEORGIA DORIS — DUKE UNIVERSITY
- Study coordinator: TOMARAS, GEORGIA DORIS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus