Understanding how antibodies can better activate immune responses
Molecular characterization and modeling efficient antibody effector function
This study is looking at how antibodies can work better with immune cells to help fight off infections and cancer, and it's for anyone interested in improving treatments for these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project ID | NIH-11016703 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which antibodies interact with immune cells to enhance their ability to target and eliminate pathogens or cancer cells. By analyzing various properties of antibodies and their targets, the study aims to identify how these interactions can be optimized for improved therapeutic outcomes. The approach includes engineering antibodies with specific characteristics to manipulate immune responses effectively, which could lead to more effective antibody-based treatments for various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with conditions that could benefit from enhanced antibody therapies, such as certain cancers or chronic infections.
Not a fit: Patients who do not have conditions that involve antibody-mediated responses may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective antibody therapies that improve patient outcomes in treating infections and cancers.
How similar studies have performed: Previous research has shown promising results in optimizing antibody functions, indicating that this approach has potential for success.
Where this research is happening
Hanover, United States
- Dartmouth College — Hanover, United States (Active)
Researchers
- Principal investigator: Ackerman, Margaret E — Dartmouth College
- Study coordinator: Ackerman, Margaret E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.