Understanding how antibodies and vaccines can help treat HIV-1
Multi-Omics Analysis of Broadly Neutralizing Antibodies and Therapeutic Vaccination
This study is looking at how certain antibodies and vaccines can help fight HIV-1 and keep the virus from coming back after treatment stops, with the hope that the findings will lead to better treatments and possibly a cure for people living with HIV.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11084511 on NIH RePORTER |
What this research studies
This research aims to explore how broadly neutralizing antibodies (bNAbs) and therapeutic vaccines can effectively combat HIV-1. By using advanced techniques to analyze immune responses and viral reservoirs in both humans and nonhuman primates, the study seeks to uncover the mechanisms that allow these treatments to delay viral rebound after stopping antiretroviral therapy. Patients may benefit from insights gained through this research, which could lead to improved strategies for HIV-1 treatment and potential cures.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV-1 who are currently on antiretroviral therapy.
Not a fit: Patients who are not infected with HIV-1 or those who are not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and possibly a cure for HIV-1.
How similar studies have performed: Previous studies have shown promise in using similar approaches to enhance HIV treatment, indicating a potential for success in this research.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Barouch, Dan H. — Beth Israel Deaconess Medical Center
- Study coordinator: Barouch, Dan H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.