Understanding how antibodies affect hepatitis E virus infection
Official title: Role of antibodies in hepatitis E virus infection
Funded at Research Inst Nationwide Children's Hosp · NIH-11061061 · Data updated 2026-11-12
This study is looking at how antibodies can help fight hepatitis E, especially for people with weakened immune systems, to see if they can prevent or treat long-lasting infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project start | April 19, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $822,317 |
| NIH project number | 5R01AI175800-03 |
| Project ID | NIH-11061061 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with chronic hepatitis E infection, particularly those with weakened immune systems.
✕Less likely to help
Patients with acute hepatitis E infections that resolve without treatment may not benefit from this research.
What this research studies
This research investigates the role of antibodies in hepatitis E virus (HEV) infection, particularly focusing on how these antibodies can potentially prevent or treat chronic HEV infections. The study examines two forms of the virus and how they interact with the immune system, especially in patients with compromised immunity. By analyzing the effectiveness of antibodies generated from natural infections and vaccinations, the research aims to uncover mechanisms that could lead to improved treatments for chronic hepatitis E. Patients may be involved in trials that assess the impact of antibody levels on disease progression and treatment outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively prevent or cure chronic hepatitis E infections, improving liver health for affected patients.
How similar studies have gone: Previous research has shown promising results in understanding the role of antibodies in viral infections, suggesting that this approach could yield significant insights into hepatitis E treatment.
Where this research is happening
-
Research Inst Nationwide Children's Hosp
Columbus, United States Active
Researchers
- Principal investigator: Feng, Zongdi — Research Inst Nationwide Children's Hosp
- Study coordinator: Feng, Zongdi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.