Understanding how antibiotics affect patients with viral sepsis
Official title: Antibiotic Utilization Patterns and Impact on Outcomes for Patients with Respiratory Viral Sepsis
Funded at Brigham and Women's Hospital · NIH-10907703 · Data updated 2026-11-12
This study looks at how often antibiotics are given to people with respiratory viral sepsis, a condition that can be mistaken for bacterial infections, to help figure out when they really need them and to make sure patients get the safest and best care possible.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $152,870 |
| NIH project number | 5K08HS029518-02 |
| Project ID | NIH-10907703 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients diagnosed with respiratory viral sepsis who may be receiving antibiotics.
✕Less likely to help
Patients with bacterial sepsis or those not diagnosed with sepsis may not benefit from this research.
What this research studies
This research investigates the patterns of antibiotic use in patients diagnosed with respiratory viral sepsis, a condition often confused with bacterial infections. It aims to clarify how frequently viruses cause sepsis and the potential harms associated with unnecessary antibiotic treatment. By analyzing extensive clinical data from over 200 hospitals, the study will identify which patients may not benefit from antibiotics and promote safer treatment practices. The ultimate goal is to improve patient safety and outcomes by refining current treatment guidelines.
Why it matters
Potential benefit: If successful, this research could lead to safer treatment protocols for patients with viral sepsis, reducing unnecessary antibiotic use and associated harms.
How similar studies have gone: While the approach of analyzing antibiotic use in viral sepsis is gaining attention, this specific research aims to provide new insights and has not been extensively tested in prior studies.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Shappell, Claire — Brigham and Women's Hospital
- Study coordinator: Shappell, Claire
Related research
Other NIH-funded projects on the same topics.
-
Role of blood flow mechanics and transfusion in sepsis-related tiny-cl vessel clots
A patient-focused look at how red blood cell flow and transfusions might influence tiny blood vessel clots and organ problems in sepsis.
-
STeroids and enhanced Antibiotics for sepsis in Africa with HIV/TB (STARS)
This grant tests whether adding steroids and stronger antibiotics helps adults with severe sepsis tied to HIV/TB in areas with high TB rates.
-
Steroids and better antibiotics for sepsis in people with AIDS in Africa
This study tests whether adding hydrocortisone and stronger antibiotics can improve survival for adults with sepsis who also have AIDS or advanced immune suppression in regions with high TB.
-
Coordinating ARDS, Pneumonia, and Sepsis research to improve care
A national coordinating center helps researchers studying ARDS and related infections work together more efficiently to learn what helps patients recover.
-
Role of MMP3 in heart dysfunction during sepsis
This research tests whether blocking MMP3 can protect the heart and improve survival during sepsis in adults.
-
Sepsis patient care guided by Ugandan-wide immune profiling
A large NIH-funded study will map how the immune system behaves during sepsis in people in Uganda to improve personalized care for sepsis patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.