NIH-funded research NIH-funded research

Understanding how ankle-foot stiffness affects comfort in prosthetic limbs

Official title: Mapping ankle-foot stiffness to socket comfort and pressure using a robotic emulator platform to personalize prosthesis function via human-in-the-loop optimization

Funded at Jesse Brown VA Medical Center · NIH-11261025 · Data updated 2026-11-12

This study is looking at how the stiffness of prosthetic ankle-foot devices affects comfort for Veterans who have had a leg amputated below the knee, and it aims to make these devices more comfortable and better suited to each person's needs by gathering their feedback.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionJesse Brown VA Medical Center
NIH-funded
Lab location1 site (Chicago, United States)
Project startFebruary 1, 2023
Project endJune 30, 2025
Funding year2025
NIH project number5I21RX004077-03
Project IDNIH-11261025 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are Veterans with transtibial amputation who use or are considering using a prosthetic limb.

Less likely to help

Patients who do not have a transtibial amputation or those who are not using prosthetic limbs may not benefit from this research.

What this research studies

This research investigates the relationship between the stiffness of prosthetic ankle-foot devices and the comfort experienced by Veterans with transtibial amputation. By using a robotic emulator platform, the study aims to measure how socket pressure impacts user comfort and satisfaction. The goal is to optimize prosthesis function through a human-in-the-loop approach, ensuring that the devices are tailored to individual needs for improved mobility and independence. Participants will provide feedback on their comfort levels, which will be used to refine prosthetic designs.

Why it matters

Potential benefit: If successful, this research could lead to more comfortable and effective prosthetic limbs for amputees, enhancing their quality of life.

How similar studies have gone: Previous research has shown that optimizing prosthetic design based on user feedback can significantly improve comfort and satisfaction, indicating a promising approach.

Where this research is happening

  • Jesse Brown VA Medical Center
    Chicago, United States
    Active

Researchers

  • Principal investigator: Major, Matthew J. — Jesse Brown VA Medical Center
  • Study coordinator: Major, Matthew J.

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.