Understanding how animals sense and respond to harmful stimuli
Official title: Molecular, Cellular, and Circuit Mechanisms of Nociception Behavior
Funded at Trustees of Indiana University · NIH-10986105 · Data updated 2026-11-12
This study is looking at how certain nerve cells in our body, called nociceptors, sense pain and harmful things, and by understanding how they work, we hope to find better ways to help people manage pain.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project start | February 10, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $350,587 |
| NIH project number | 5R35GM148258-03 |
| Project ID | NIH-10986105 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals suffering from chronic pain or sensory processing disorders.
✕Less likely to help
Patients with acute pain conditions or those not experiencing sensory processing issues may not receive direct benefits from this research.
What this research studies
This research investigates the mechanisms by which specialized neurons, known as nociceptors, detect potentially harmful stimuli. By studying the genetic and cellular characteristics of these neurons, the research aims to uncover how different types of sensory neurons function and communicate. The approach involves using model organisms to explore the gene expression patterns and morphological features of these neurons, which could lead to a better understanding of pain perception and sensory processing. Patients may benefit from insights gained into how pain signals are processed in the nervous system.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for pain management and improved understanding of sensory disorders.
How similar studies have gone: Previous research has shown success in understanding nociception mechanisms, indicating that this approach has potential for meaningful advancements.
Where this research is happening
-
Trustees of Indiana University
Bloomington, United States Active
Researchers
- Principal investigator: Tracey, William D — Trustees of Indiana University
- Study coordinator: Tracey, William D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.