Understanding how animal cells develop and differentiate
The ancestry of animal cell differentiation and pluripotency
This study looks at how animal cells change into different types and jobs by exploring tiny organisms called choanoflagellates, which are closely related to animals, to understand the genes and surroundings that help guide these changes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10867460 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind how animal cells differentiate into various types and functions. By studying choanoflagellates, which are the closest living relatives of animals, the research aims to uncover the genetic and environmental cues that influence cell differentiation. The approach involves advanced techniques such as gene delivery and genome editing to explore how these unicellular organisms respond to their environments. The findings could provide insights into the fundamental processes of cell biology that are relevant to both animals and humans.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals interested in the biological mechanisms of cell differentiation and their implications for health.
Not a fit: Patients with conditions unrelated to cell differentiation or those not interested in biological research may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of cell differentiation, potentially leading to advancements in regenerative medicine and treatments for various diseases.
How similar studies have performed: Other research has shown success in using model organisms to understand cell differentiation, indicating that this approach has a solid foundation in scientific inquiry.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Booth, David Scott — University of California, San Francisco
- Study coordinator: Booth, David Scott
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.