Understanding how ANGPTL3 and ANGPTL8 proteins move within cells
Official title: Mechanism of Intracellular ANGPTL3 and ANGPTL8 Trafficking
Funded at Univ of North Carolina Chapel Hill · NIH-10998676 · Data updated 2026-11-12
This study is looking at two proteins, ANGPTL3 and ANGPTL8, to understand how they work together in managing fat levels in the body and how this affects heart health, which could help us find new ways to treat related diseases.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | September 30, 2024 |
| Project end | September 29, 2026 |
| Funding year | 2024 |
| Award (this year) | $40,064 |
| NIH project number | 1F31HL176142-01 |
| Project ID | NIH-10998676 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with high lipid levels or those at risk for cardiovascular diseases.
✕Less likely to help
Patients who do not have issues related to lipid metabolism or cardiovascular diseases may not benefit from this research.
What this research studies
This research investigates the behavior of two proteins, ANGPTL3 and ANGPTL8, which play important roles in lipid metabolism and cardiovascular health. The study aims to uncover how these proteins interact and why ANGPTL8 is unstable without ANGPTL3. By visualizing the dynamics of their complex within cells, researchers hope to gain insights into their functions and implications for diseases related to lipid levels in the blood. This could lead to a better understanding of cardiovascular diseases and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing lipid levels and reducing the risk of cardiovascular diseases.
How similar studies have gone: Previous research has shown that understanding protein interactions in lipid metabolism can lead to significant advancements in cardiovascular disease treatment.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: So, Christina — Univ of North Carolina Chapel Hill
- Study coordinator: So, Christina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.