Understanding how anesthetics might affect future generations
Mechanisms and blood-based biomarkers of intergenerational neurobehavioral effects of general anesthetics
This project explores how general anesthetics given to parents might influence the brain development and behavior of their children, especially looking for clues in the blood.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11123134 on NIH RePORTER |
What this research studies
We are looking into how common anesthetics might cause changes in parents' cells that could be passed down to their children, potentially affecting their brain development. Our work focuses on understanding the specific biological steps involved, such as how stress hormones and certain brain signals play a role. We also want to find markers in the blood that could tell us if these changes are happening. This knowledge could help us develop ways to prevent these effects in the future, particularly for neurodevelopmental disorders that are becoming more common.
Who could benefit from this research
Good fit: This foundational preclinical work does not directly involve patient participation but aims to benefit future generations by understanding the effects of general anesthetics on parents.
Not a fit: Patients not planning to have children or those without concerns about neurodevelopmental disorders in their offspring may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or reduce the risk of neurodevelopmental disorders in children whose parents have received general anesthesia.
How similar studies have performed: This research explores novel mechanisms and intergenerational effects of anesthetics, building on existing knowledge but venturing into less explored areas.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Martynyuk, Anatoly E — University of Florida
- Study coordinator: Martynyuk, Anatoly E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.