Understanding how anesthesia affects people differently based on their individual characteristics
Personalized Anesthetic Pharmacology Across the Lifespan
This study is looking at how different anesthetic drugs affect older adults, with the goal of finding better ways to tailor treatments for them based on their unique needs, so they can recover more smoothly after surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10903777 on NIH RePORTER |
What this research studies
This research investigates how anesthetic drugs impact individuals differently, particularly focusing on the elderly population. It aims to develop personalized measures of drug effects rather than relying on standard population-based dosing guidelines. By studying anesthetic responses in mice, the researchers are exploring how individual histories and states of arousal influence recovery from anesthesia. The goal is to improve outcomes for patients who may experience complications like postoperative delirium and cognitive dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research include elderly patients undergoing anesthesia for surgical procedures.
Not a fit: Patients who are not undergoing surgery or who are younger than 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more tailored anesthetic dosing, reducing complications and improving recovery for patients, especially the elderly.
How similar studies have performed: While the approach of personalizing anesthetic dosing is gaining attention, this specific methodology of assessing individual responses is relatively novel and has not been extensively tested.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Kelz, Max — University of Pennsylvania
- Study coordinator: Kelz, Max
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.