Understanding how anemia affects brain oxygen delivery and infarct mechanisms
Mechanisms of cerebral infarcts and brain oxygen utilization in anemia
This study looks at how anemia affects the way oxygen gets to the brain and how that might lead to problems like strokes or Alzheimer's, using special imaging to see blood flow and oxygen use in people with anemia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11054578 on NIH RePORTER |
What this research studies
This research investigates how anemia influences the delivery of oxygen to the brain and the mechanisms behind cerebral infarcts. It focuses on the role of blood capillary transit time and how it affects tissue oxygen extraction, particularly in individuals with anemia. The study utilizes advanced imaging techniques, such as arterial spin labeling MRI, to observe blood flow and oxygen utilization in the brain. By examining these factors, the research aims to uncover potential markers that could help in managing conditions like stroke and Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with anemia, particularly those affected by sickle cell anemia, as well as patients with conditions like stroke or Alzheimer's disease.
Not a fit: Patients without anemia or those not experiencing neurological conditions related to oxygen delivery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with anemia and related neurological conditions by enhancing our understanding of brain oxygen delivery.
How similar studies have performed: Previous research has shown promising results in understanding blood flow dynamics in similar conditions, indicating that this approach may yield valuable insights.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Donahue, Manus J — Vanderbilt University Medical Center
- Study coordinator: Donahue, Manus J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.