Understanding how ancestry affects prostate cancer aggressiveness in African American men
Investigating the mechanisms of driver genes associated with ancestry and aggressiveness in prostate cancer
This study is looking at how genetics might explain why African American men often have more aggressive prostate cancer compared to European American men, and it aims to find out what specific changes in their genes could lead to worse outcomes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11072127 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that contribute to the higher rates of aggressive prostate cancer in African American men. By analyzing tissue samples from both African American and European American men, the study aims to identify unique genomic alterations that may lead to more severe disease outcomes. The researchers will utilize advanced techniques such as whole exome sequencing and single-cell RNA sequencing to explore the molecular differences in prostate cancer biology. Additionally, they will create new cell models to test the effects of specific genes on cancer progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are African American men diagnosed with prostate cancer, particularly those with low-risk disease.
Not a fit: Patients who do not have prostate cancer or those from other racial backgrounds may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for prostate cancer in African American men.
How similar studies have performed: Previous research has shown promising results in understanding genetic factors in cancer disparities, indicating that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Campbell, Joshua D — Boston University Medical Campus
- Study coordinator: Campbell, Joshua D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.