Understanding how amyloid plaques affect Alzheimer's disease progression
Official title: Insights into Amyloid Pathogenicity Dynamics
Funded at Northwestern University at Chicago · NIH-10754960 · Data updated 2026-11-12
This study is looking at how amyloid plaques in the brains of people with Alzheimer's disease change over time and how they relate to other brain changes, with the hope of finding new ways to understand and treat the condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | December 15, 2022 |
| Project end | November 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $170,112 |
| NIH project number | 5R21AG080705-02 |
| Project ID | NIH-10754960 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those showing early signs of cognitive decline.
✕Less likely to help
Patients with other forms of dementia unrelated to amyloid pathology may not benefit from this research.
What this research studies
This research investigates the dynamics of amyloid plaques in the brains of individuals with Alzheimer's disease (AD). It aims to map the development and diversity of these plaques and their relationship to neurofibrillary tangles, which are also associated with AD. By analyzing brain samples, the research seeks to uncover how these amyloid aggregates change over time and contribute to cognitive decline. This could lead to better understanding and potential new treatments for AD.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for diagnosing and treating Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding amyloid pathology, but this specific approach to mapping plaque dynamics is relatively novel.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Savas, Jeffrey Nicholas — Northwestern University at Chicago
- Study coordinator: Savas, Jeffrey Nicholas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.