Understanding how amyloid fibrils form in diseases like Alzheimer's and diabetes
Official title: Probing Amyloid Fibril Self-Assembly with Network Hamiltonian Simulations in Explicit Space
Funded at San Jose State University · NIH-10908597 · Data updated 2026-11-12
This study is looking at how certain proteins clump together in the early stages, which is important for understanding diseases like Alzheimer's and type 2 diabetes, and it aims to find new ways to help patients by figuring out how these clumps form in tight spaces.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Jose State University NIH-funded |
| Lab location | 1 site (San Jose, United States) |
| Project start | August 16, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $178,937 |
| NIH project number | 5R16GM150706-02 |
| Project ID | NIH-10908597 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or type 2 diabetes, as well as those at risk for these conditions.
✕Less likely to help
Patients with conditions unrelated to amyloid fibril formation may not receive any benefit from this research.
What this research studies
This research investigates the formation of amyloid fibrils, which are linked to diseases such as Alzheimer's and type 2 diabetes. By using advanced computer simulations and microscopy techniques, the researchers aim to uncover the mechanisms behind the initial stages of fibril formation. The study focuses on how these fibrils develop in confined environments, which may provide insights into disease onset. Patients may benefit from a better understanding of these processes, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent diseases associated with amyloid fibril formation.
How similar studies have gone: Previous research has shown promising results in understanding amyloid fibril formation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
San Jose State University
San Jose, United States Active
Researchers
- Principal investigator: Grazioli, Gianmarc — San Jose State University
- Study coordinator: Grazioli, Gianmarc
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.