Understanding how amyloid beta proteins clump together during metabolic stress
Official title: Investigating the aggregation of amyloid β during metabolic stress using multiscale modeling
Funded at University of South Florida · NIH-10933870 · Data updated 2026-11-12
This study is looking at how certain changes in the brain can cause proteins related to Alzheimer's disease to clump together, which might help us understand more about the disease and how it develops, so that patients can benefit from new insights into their condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $200,323 |
| NIH project number | 1R21AG087910-01 |
| Project ID | NIH-10933870 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for Alzheimer's disease, particularly those experiencing metabolic stress or related neurological conditions.
✕Less likely to help
Patients with advanced Alzheimer's disease or those not experiencing metabolic stress may not benefit from this research.
What this research studies
This research investigates the conditions that lead to the clumping of amyloid beta proteins, which are linked to Alzheimer's disease, particularly during episodes of metabolic stress in the brain. By using advanced modeling techniques, the researchers aim to simulate how these proteins behave under various physiological conditions, such as changes in pH and ion concentrations. The goal is to uncover the mechanisms behind amyloid aggregation, which could provide insights into the onset and progression of Alzheimer's disease. Patients may benefit from a better understanding of how metabolic stress contributes to their condition.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting the mechanisms of amyloid aggregation.
How similar studies have gone: Previous research has shown that understanding the aggregation of amyloid proteins can lead to significant advancements in Alzheimer's treatment, indicating that this approach has potential for success.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Ullah, Ghanim — University of South Florida
- Study coordinator: Ullah, Ghanim
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.