Understanding how amyloid-beta interacts with inflammasome proteins
Official title: Mechanisms of NLRP3 inflammasome activation
Funded at University of Missouri-St. Louis · NIH-11036891 · Data updated 2026-11-12
This study is looking at how certain proteins related to inflammation interact with amyloid-beta, which is important for understanding diseases like Alzheimer's, and it also helps students learn new scientific skills along the way.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-St. Louis NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $85,184 |
| NIH project number | 3R15GM152964-01S1 |
| Project ID | NIH-11036891 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals under 20 years of age who may be at risk for or affected by Alzheimer's disease or related conditions.
✕Less likely to help
Patients over 20 years of age or those not affected by Alzheimer's disease may not receive direct benefits from this research.
What this research studies
This research investigates the interactions between amyloid-beta peptides and proteins that make up the NLRP3 inflammasome, which is involved in inflammatory responses in the body. Using advanced imaging technology, the study aims to characterize how these interactions influence inflammasome function. The research will enhance the training of undergraduate students at the University of Missouri-St. Louis, allowing them to engage in cutting-edge scientific techniques. The findings could provide insights into the mechanisms underlying neurodegenerative diseases like Alzheimer's.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of Alzheimer's disease mechanisms and potentially inform new therapeutic strategies.
How similar studies have gone: Previous research has shown promise in understanding the role of inflammasomes in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Missouri-St. Louis
Saint Louis, United States Active
Researchers
- Principal investigator: Nichols, Michael R. — University of Missouri-St. Louis
- Study coordinator: Nichols, Michael R.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.